About the Role
Do you like hard technical challenges solved with modern technology - cloud, microservices, and applied AI/LLM systems? Join our team to develop and deliver web modules and microservices for a globally distributed platform that connects hospitals and labs. You'll focus on genomics interpretation, data processing, and analysis, using AI to contribute to our SaaS platform that transforms how complex healthcare data is shared and utilized. Join the SOPHiA GENETICS Software Engineering team as our new Full Stack Software Engineer, and enable us to make a positive impact on the outcomes for cancer and rare disease patients worldwide.
This is a hybrid opportunity, requiring 3 days onsite at our corporate office in either Bidart, FR or Rolle, CH (or Boston, MA). Please ensure that all CV/Resumes are submitted in English as we are an international company that uses English as our language of business. Our cloud-native AI powered SOPHiA DDM Platform makes data-driven decisions in healthcare a daily reality. You will have direct input to our mission to democratize data-driven medicine for the ultimate benefit of cancer and rare disease patients across the globe.
Responsibilities
We are looking for a Senior AI Software Engineer to strengthen our Engineering Hub — a small, nimble team that takes new product ideas from 0 to 1. You will be a builder and a mentor: shipping full-stack product features, and bringing hands-on experience with production LLM applications so the whole team levels up. Your first flagship AI project will draft evidence-grounded gene and variant descriptions, with sources and citations, for clinical interpreters to review.
Product engineering
•Design, build, test, deploy and maintain full-stack web features and microservices, owning components end to end.
•Lead code and design reviews; mentor junior engineers and raise the team's engineering quality.
•Prototype fast and iterate — take early ideas to working, reliable software.
•Collaborate with Product, QA, Architecture and PMO to align delivery with product vision and regulatory needs.
Applied AI / LLM
•Build retrieval-augmented generation (RAG) pipelines over curated clinical data sources and internal databases.
•Design system and task-specific prompts, structured output, and provenance/citation handling.
•Build LLM evaluation into the product: graders and evaluation pipelines that score accuracy, relevance and grounding, plus guardrails that verify citations resolve and are relevant.
•Use managed LLM endpoints on Azure AI Foundry effectively (caching, tools, structured output), and share these practices with the team.
Requirements
•5–7 years building and releasing reliable web-based services to production.
•Back-end: strong Java and SQL, microservice architecture.
•Front-end: React and modern JavaScript.
•Containerization and orchestration (Docker, Kubernetes) and CI/CD.
•Hands-on experience with production LLM applications — specifically RAG pipelines and/or LLM evaluation — OR clear, demonstrable evidence of rapidly self-learning new technical areas to production quality.
•Experience using AI tooling in the SDLC (AI-assisted coding, review, documentation).
•Strong communication and a real appetite for mentoring.
•Bachelor's degree in Computer Science / Engineering, or equivalent professional experience.
Strong plus
•Prompt engineering, structured/JSON output, and reasoning about faithfulness, calibration and hallucination.
•Experience with Azure AI Foundry or equivalent managed inference platforms; prompt caching.
•GraphQL, observability (Grafana, Loki), modern DevOps.
•Experience in genomics, digital healthcare, or another regulated domain.
Conditions and Benefits
You will be joining an organization with the patient at the heart of every decision and action, driven by purpose as we pursue exponential growth. Business recognition and accolades include: World's most innovative companies (Top 10), World's smartest companies (Top 50), 100 Best Places to Work in Boston, Top 10 European Tech Startup, Top 10 European biotechs startup to watch, Top 25 East-Coast Biotech to watch.
Benefits package varies internationally in-line with local standards and laws. Overview includes:
•Sickness and Accident coverage through Helsana
•Meal Vouchers at 90 CHF per month with our partner cafeteria
•A fun and engaging work environment, with Rest & Entertainment space, fully stocked free coffee machine and free fruit/snacks
•Free parking in an easy to access location
•A strong social committee
•Direct interaction and exposure to senior leadership and the executive team locally (as our global HQ)
Start Date: ASAP
Location: Bidart, FR or Rolle, CH or Boston, MA (Hybrid, 3 days onsite)
Contract: Permanent
MA Pay Range: USD 88,000 - 168,000 (estimated pay range for candidates based in Massachusetts; may vary by location and does not include benefits, bonus, commission, or equity)
